網頁从机制上讲，STING 的 CBD 结构域中的 Q237、E316 和 S322 是与 NCOA4 的卷曲螺旋结构域相互作用的关键结合位点。. 它们的相互作用不仅触发了铁蛋白吞噬介导的铁死亡， … 網頁SN-001, but not SN-100, decreased cytosolic DNA-induced phosphorylation of STING, TBK1, IRF3, IκBα, and p65, as well as nuclear translocation of IRF3 and p65. …
聚焦药靶：STING——使肿瘤由“冷”转“热”的免疫治疗靶点 - CN …
網頁2024年5月18日 · In addition to its role in activating STING, nuclear cGAS has also been implicated in inhibiting DNA repair via homologous recombination, but how certain types … 網頁2024年4月19日 · Dunphy, G. et al. Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-kappaB signaling after nuclear DNA damage. … dale farm holidays treehouse
PD-L1抑制剂抗癌新机制！STING通路功不可没 - 知乎
網頁2024年7月19日，南开大学 曹雪涛 院士团队在 Science 期刊上以长文形式在线发表了题为 Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses … 網頁2024年4月11日 · North Korean crypto heist funding nuclear ambitions. 03:25. Former Maryland Gov. Hogan's ex-chief of staff dies after confrontation with FBI agent. 02:24. What companies might lose by forcing ... 網頁2024年9月24日 · We further show that STING mobility in the NE increases with both DNA- and RNA-triggered immune responses. Moreover, we identify partners of NE localized … dale farm eviction