Dynamo mapping vector field of single cells
WebFeb 17, 2024 · In this work, we introduced dynamical systems theory and differential geometry analyses to single-cell genomics. A dynamical system describes the time … WebQiu X, Zhang Y, Yang D, et al. Mapping vector field of single cells[J]. Biorxiv, 2024. 这个 RNA velocity and beyond 系列之后大概会写 Theory 部分 ，主要介绍 model detail，怎么 estimate parameter等，最后写 beyond 的部分，也就是dynamo 的内容。 欢迎大家在评论区讨论（虽然我估计没什么人看hhhh）
Dynamo mapping vector field of single cells
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Web•Vector fields reveal the timing and mechanisms of human hematopoiesis •Dynamo allows cell-state transition path and in silico perturbation predictions . Summary. Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. WebInclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction and differential geometry analyses - GitHub - KBRI-Biology-Experiment-Comput...
WebLeveraging the least-action-path method, dynamo accurately predicts drivers of numerous hematopoietic transitions. Finally, in silico perturbations predict cell-fate diversions induced by gene perturbations. Dynamo, thus, represents an important step in advancing quantitative and predictive theories of cell-state transitions. WebDynamo: Mapping Vector Field of Single Cells¶ Understanding how gene expression in single cells progress over time is vital for revealing the mechanisms governing cell fate …
WebFeb 1, 2024 · The researchers confirmed dynamo 's cell fate predictions by testing it against cloned cells-cells that share the same genetics and ancestry. One of two nearly-identical clones would be sequenced ... Web•Vector fields reveal the timing and mechanisms of human hematopoiesis •Dynamo allows cell-state transition path and in silico perturbation predictions . Summary. Single-cell …
WebApr 10, 2024 · RNA degradation kinetics vector visualization and transcriptomic vector field animation by dynamo. ... X. et al. Mapping transcriptomic vector fields of single cells. ... Simultaneous mapping and ...
http://dynamo-readthedocs.readthedocs.io/ on the real structure of gypsum crystalsWebDeciphering gene regulation through vector fields analysis in pancreatic endocrinogenesis¶. cellDancer could be integrated into downstream analysis, such as dynamo proposed by Qiu et al.. In this tutorial, the output of cellDancer (PancreaticEndocrinogenesis_cellDancer_estimation.csv) in pancreatic … on the reasons behind decisionsWebFeb 18, 2024 · To enable such temporal analysis from multimodal single-cell experiments, we introduce an extension of the RNA velocity method that leverages estimates of unprocessed transcript and protein abundances to extrapolate cell states. ... Wang L, Yuan R, et al. Mapping Vector Field of Single Cells. Biorxiv. 2024;9:696724. Google Scholar … on the reasonableness of christianityWebJul 9, 2024 · The reconstructed vector field further enables global mapping of potential landscapes that reflects the relative stability of a given cell state, and the minimal … on the rearWebFeb 1, 2024 · Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these data, however, requires ... on the rear sideWebJul 9, 2024 · Here, we introduce dynamo , an analytical framework that reconciles intrinsic splicing and labeling kinetics to estimate absolute RNA velocities, reconstructs velocity vector fields that predict future cell fates, and finally employs differential geometry analyses to elucidate the underlying regulatory networks. ioqjs study materialWebJul 9, 2024 · Single-cell RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these … on the real tho dobre brothers