Cyclopropane mycolic acid synthase
WebJan 18, 2015 · Rv0470c-cyclopropane mycolic acid synthase 3 (mycolic acid methyltransferase) participates in lipid metabolism by catalyzing the transfer of a methylene group from S-adenosyl-l-methionine to form a cyclopropane ring at the proximal position of a fatty acid. Several different fatty acids can be used as substrates for this enzyme such … WebThe major mycolic acid produced by Mycobacterium tuberculosis contains two cis -cyclopropanes in the meromycolate chain. The gene whose product cyclopropanates the …
Cyclopropane mycolic acid synthase
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WebSeveral studies indicate that functional groups in the acyl chain of mycolic acids are important for pathogenesis and persistence. There are at least three mycolic acid … WebApr 6, 2024 · Rice is a staple food crop for more than half of the world’s population. Many rice-growing regions, especially in South and Southeast Asia, are in flood-prone lowland areas [].Flash flooding due to unpredicted rainfall is a common phenomenon in such areas, severely affecting rice crops in various stages of their development, requiring different …
WebGene ID: 886284, updated on 12-Feb-2024 Summary Other designations cyclopropane mycolic acid synthase GeneRIFs: Gene References Into Functions mycolic acid cyclopropane synthase PcaA, but not MmaA2, was phosphorylated by mycobacterial Ser/Thr kinases at Thr-168 and Thr-183 WebJul 5, 2004 · Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence. 2 publications Catalytic activity 1 …
WebDec 30, 2001 · There are at least three mycolic acid cyclopropane synthases (PcaA, CmaA1, and CmaA2) that are responsible for these site-specific modifications of … WebFeb 7, 2024 · The fatty acid synthase type II (FAS-II) multienzyme system builds the main chain of mycolic acids (MAs), important lipid pathogenicity factors of Mycobacterium …
WebMay 25, 2011 · There are two principle classes of bacterial cyclopropane synthases: the Escherichia coli cyclopropane synthase (ECPS) type that uses unsaturated phospholipids as substrates and Mycobacterium tuberculosis cyclopropane mycolic acid synthases (CMAs) that perform the introduction of cis-cyclopropane rings at proximal and distal …
WebMar 29, 2024 · Cyclopropane Mycolic acid synthases (CMAS) are a family enzymes with a methyl transferase activity which act by transferring a methyl group from S-adenosyl-l … pop up camper rentals txWebMycolic acids are major and specific lipid components of the mycobacterial cell envelope and are essential for the survival of members of the genus Mycobacterium that contains the causative agents of both tuberculosis … pop up camper prices usedWebAug 8, 2024 · Thus far, novel inhibitors for various enzymes (e.g., enoyl-acyl carrier protein reductase [17,18,19], mycobacterial cyclopropane mycolic acid synthase 1 , and 7, 8-diaminopelargonic acid synthase ... sharon kwan arcadiaWebCycloproponated mycolic acids make the cell wall less permeable, contribute to antibiotic resistance and host immunomodulation and protect from injury. Cyclopropanation is … sharon kunin brownWebDec 6, 2004 · Escherichia coli fatty acid cyclopropane synthase (CFAS) was overproduced and purified as a His 6-tagged protein.This recombinant enzyme is as active as the native enzyme with a K m of 90 µ m for S-AdoMet and a specific activity of 5 × 10 −2 µmol·min −1 ·mg −1.The enzyme is devoid of organic or metal cofactors and is unable to … pop up camper redoing floor and wallsWebApr 6, 2024 · cyclopropane, also called trimethylene, explosive, colourless gas used in medicine since 1934 as a general anesthetic. Cyclopropane is nonirritating to mucous … pop up camper refrigerator replacementWebApr 18, 2024 · The E. coli enzyme is the prototype for this class of enzymes, which include the cyclopropane mycolic acid (CMA) synthases, which are potential targets for the … pop up camper rental iowa