Ctgf tgf-beta signaling
The primary cultures of orbital fibroblasts were established from surgical specimens of 4 patients with GO (G1-G4) during decompression surgery (one men and three women; mean age: 37.2 years) and from apparently normal orbital tissues in four age- and sex-matched patients (N1-N4), who received surgery for … See more The recombinant human TGF-β1 (#P01137) and TGF-β2 (#P61812) were purchased from R&D Systems, Inc. (Minneapolis, MN, USA), and the recombinant human CTGF protein (#PHG0286) was … See more The intracellular contents of human transforming growth factor-beta 1 (TGF-β1; catalog #DB100B) was quantified in cell culture supernatant by an enzyme-linked … See more About 1 × 107 cells were trypsinized, pelleted, washed with PBS, and then resuspended in the lysis buffer containing 50 mM Hepes (pH 7.4), 4 mM EDTA, 2 mM EGTA, 1 mM Na3VO2, 1 mM NaF, 1% Triton X-100, and … See more The small hairpin RNA (shRNA) plasmids for the CTGF gene (shCTGF) and luciferase control gene (shLuc) were obtained from the RNAi Core Facility at Academia Sinica, Taipei, Taiwan. The shLuc and shCTGF … See more WebApr 11, 2024 · Role of TGF-β in HSC activation mediated by HBV-infected hepatocytes. TGF-β is a vital regulator of inflammation and fibrosis [] and participates in the …
Ctgf tgf-beta signaling
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WebThis detailed volume is devoted to the recent development of quantitative experiments and computational methods driving new transforming growth factor beta (TGF-β) and other cell signaling knowledge. Many chapters cover quantitative assays for TGF-β signaling studies, with others exploring the increasing role of both modeling and ... WebThis detailed volume is devoted to the recent development of quantitative experiments and computational methods driving new transforming growth factor beta (TGF-β) and other …
WebMar 9, 2024 · Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling. In repetitive strain injury, substance P immunoexpression increased in week 12 peritendon as did CTGF-immunopositive fibroblasts. CTGF expression in epithelium was up-regulated early and urinary CTGF was markedly elevated from … WebThe Smad2/3 pathway plays a key role in mediating TGF-β1 inhibition of branching morphogenesis and induction of connective tissue growth factor (CTGF) expression in embryonic lungs. Because a ...
WebApr 9, 2024 · Angiotensin II (Ang II) upregulates transforming growth factor-beta1 (TGF-β1) and endothelin-1 (ET-1) in various types of cells, and all of them act as … WebTGF beta signaling is well known to contribute to processes involving the ocular anterior segment and IOP 113 as well as the glaucoma-related ... Intuitively, these effects should …
WebLike TGF-β, CTGF expression is increased in IPF patients. 104 Overexpression of CTGF can promote pulmonary fibrosis in animal models, 105 and blockade of CTGF signaling …
WebAug 1, 2024 · Upregulation of PTHLH, IL11, CTGF, and JAGGED1 is dependent on TGFβ/Smad signaling to enhance osteolytic metastasis in breast carcinoma and melanoma cells . Furthermore ... The miR-106b-25 cluster targets Smad7, activates TGF-beta signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 … css card headerWebTGF-β1 can serve as a driver in wound healing, tissue repair and excessive ECM accumulation. 1 TGF-β1 can also directly activate Smad signaling and trigger … ear doctor markhamWebIt was reported that both STAT3 and TGF-β1 signaling pathways coordinate to ... Col1A1, Col 3A1, and CTGF were significantly lower in the C7A + TAA group than saline + TAA group (Figure 6E). Furthermore ... isolated from U. davidiana var. japonica, in transforming growth factor beta (TGF-β1)-induced activated HSCs and thioacetamide (TAA ... css card horizontalWebApr 15, 2011 · The contribution of transforming growth factor β (TGF-β) signaling to breast cancer has been studied for more than two decades. In an early phase TGF-β may act as a tumour suppressor, while later, when cells have become resistant to its anti-mitogenic effects, the role of TGF-β switches towards malignant conversion and progression. ear doctor massachusettsWebJun 6, 2012 · CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, … ear doctor lynchburg vaWebDec 22, 2015 · Thus, heightened activation of YAP1/TAZ, CTGF, TGF-βs–SMADs, JAG1, and SPP1 may contribute to the abnormalities in LMob1DKO liver. Alternatively, the observed increase in growth factors such as ... L Akkari, et al., Cell shape and TGF-beta signaling define the choice of lineage during in vitro differentiation of mouse primary … ear doctor melbourne flWebThe transforming growth factor–β (TGF-β) family of secreted proteins is implicated in the control of widely diverse physiologies and its dysregulation with disease. In this review, which contains 7 figures and 343 references, we describe the exquisite nature of TGF-β family signaling in its roles in diverse and context-specific cellular ... css card hover animations