Clinimacs prodigy specifications

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August undefined, 2024

WebFeb 8, 2024 · The CliniMACS Prodigy® is such a platform that combines automation with processing in a single-use, closed-system tubing set. It supports automation of predefined processes, for instance T cell …

Flow cytometric appearance of CliniMACS Plus or Prodigy …

WebDec 1, 2024 · Prodigy runs took about 1 h longer than CliniMACS Plus runs, albeit with markedly less hands-on operator time and therefore also suitable for less experienced operators. Recovery of target cells ... WebGMP cell therapy manufacturing with the CliniMACS Prodigy® Platform. Small- to large-scale, highly automated yet thoroughly customizable, our cell manufacturing solution … mountainstills.com

CliniMACS Prodigy® Automated cell processing with the …

WebNov 5, 2024 · All PBMC vials for a given donor were thawed and pooled. Thawed PBMCs (0.93-1.17e8 cells) were loaded onto a CliniMACS Prodigy device, CD4 and CD8 T cells enriched by immunomagnetic sorting, and T cells placed in the culture chamber with IL-7, IL-15 and TransAct reagent to induce proliferation. WebJun 16, 2024 · We performed process optimization from the research laboratory setting to clinical-grade manufacturing using the CliniMACS Prodigy system, a fully closed, automated, flexible, and user-defined platform that enables reproducible, scalable, and clinical-grade manufacturing of cell products with a single-use tubing system ( 8 ). WebMay 1, 2024 · Here we will highlight efforts to scale-up the system and develop a fit-for-purpose platform process that can satisfy emerging T-cell engineered therapies’ … hearns johnson institute

(PDF) Optimal large‐scale CD34+ enrichment from a …

Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed

WebFlow cytometric appearance of CliniMACS Plus or Prodigy generated CD34 selection products: excerpts from the flow cytometric analysis (quality control) of the final products from all three runs... WebFeb 1, 2024 · After leukapheresis and washing, T cell subsets (CD4, CD8, CD25 etc.) are enriched by using immunomagnetic separation on the Miltenyi CliniMACs and Prodigy devices) 10. This step is performed by … mountains that start with zWebCliniMACS® and MACS® GMP Products Amount required CliniMACS Prodigy with T Cell Transduction– Large Scale application software 1 CliniMACS CD4 and CD8 Reagent/GMP MicroBeads 1 piece each CliniMACS CD62L Reagent/GMP MicroBeads 1 piece CliniMACS Prodigy TS 620 1 piece CliniMACS PBS/EDTA Buffer (3 L) 1 piece … mountains that start with v

"WebJun 29, 2024 · To examine the feasibility of manufacture of autologous CD19 CAR T-cells at a minimum target dose of 1 X 106 cells/kilogram using the Miltenyi CliniMACS Prodigy® automated system Incidence and severity of adverse events [ Time Frame: 3 years ] To determine the safety of infusion with chimeric antigen receptor T cells targeting CD19 " - Clinimacs prodigy specifications

Clinimacs prodigy specifications

Therapeutic Products: Cell Processing Facility - Fred …

WebThe CliniMACS CD34 Reagent System is indicated for processing hematopoietic progenitor cells collected by apheresis (HPC, Apheresis) from an allogeneic, HLA-identical, sibling donor to obtain a... WebMar 20, 2024 · Our system is based on the use of a closed semi-automatic bioreactor (CliniMACS Prodigy ®) for ex vivo selection, transduction and expansion of CAR T-cells. We are currently conducting a phase I clinical …

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WebSep 1, 2024 · Fully automated systems such as the CliniMACS Prodigy (Miltenyi Biotec) and the Cocoon (Lonza) are capable of isolating T cells (either CD3 + or CD4/CD8 … WebAll aspects of the CPF are maintained according to specifications set by Code of Federal Regulations title 21, sections 210 and 211, to meet current GMP (cGMP). ... Miltenyi CliniMACS Plus for cell separation and …

WebAug 7, 2024 · We hypothesized that point of care manufacturing of CAR-T cells on the automated CliniMACS Prodigy® device allows reproducible and fast delivery of cells for the treatment of patients with non-Hodgkin lymphoma. Here we describe cell manufacturing results and characterize the phenotype and effector function of CAR-T cells used in a … WebDec 7, 2024 · The recently introduced CliniMACS Prodigy® (Miltenyi Biotec) permits automated selection of CD34+ cells from mobilized peripheral blood stem cells (PBSCs) …

WebSpecifications Specifications for CliniMACS Prodigy ® Tubing Set 500 Overview The CliniMACS Prodigy ® TS 500 is a single-use, biocompatible tubing set used in the … WebOct 1, 2024 · Upon installation of the closed, single-use tubing set on the CliniMACS Prodigy™, sterile welding of the starting cell product, and sterile connection of the required reagents, T cells are magnetically enriched, stimulated, transduced using lentiviral vectors, expanded, and formulated.

WebMar 16, 2024 · This protocol describes the use of an automated cell processor and culture system, the CliniMACS Prodigy device sold by Miltenyi Biotec, for the local manufacture of CAR T-cells targeting the CD19 antigen. The manufacturing process will use a lentiviral vector (CAR19) provided by Lentigen, a wholly owned subsidiary of Miltenyi Biotec, to ...

WebWith the CliniMACS Prodigy® Platform and the MACSQuant® Analyzer at the core, all our cell manufacturing locations worldwide are built and equipped on this same principle for consistent manufacturing and analytical processes. Harmonization among all instruments allows for an easy technology and assay transfer around the globe. mountains to beach halfWebApr 4, 2024 · Utilising the state-of-the-art, automated cell processing platform CliniMACS Prodigy ®, Autolus has established a GMP production process for its programmed T cell therapies designed to address the challenges of commercial-scale manufacturing. Parallel processing of a large number of patient samples in closed systems is key to achieving ... hearns jewelryWebCliniMACS Prodigy Platform Automated cell manufacturing on a closed and scalable platform The CliniMACS Prodigy® is an automated cell processing platform that … hearns kenilworth