Cisplatin hyponatremia

Author: cwmk

August undefined, 2024

WebSep 1, 2002 · Other clinical features of cisplatin nephrotoxicity include hypomagnesemia, Fanconi-like syndrome (glucosuria, phosphaturia, and aminoaciduria), renal-salt wasting, and chronic renal failure.... WebMar 24, 2024 · Hyponatremia has been a recognized complication of platinum-based chemotherapy for decades. 7,8 There is limited data to quantify the overall incidence of …

An integrated analysis of hyponatremia in cancer patients …

WebApr 6, 2024 · Treatment-related grade 3/4 hyponatremia was reported in 5%–7% of MIBC patients treated with pre-operative ... NAC and prolonged survival. 34-36 It is hypothesized that these mutations may increase the sensitivity of tumor cells to cisplatin-induced DNA damage, thereby enhancing the drug's efficacy in these tumors. 37 The incidence of DDR ... WebMay 17, 2024 · Hyponatremia occurs when the concentration of sodium in your blood is abnormally low. Sodium is an electrolyte, and it helps regulate the amount of water that's … darwin homes atlanta ga

Cisplatin induced hyponatremia; looking deeper - Renal …

WebDec 20, 2024 · Background: Hyponatremia is a common electrolyte abnormality in cancer patients who receive chemotherapy. Among anticancer agents, platinum-based agents are reported to cause chemotherapy-induced hyponatremia. However, the actual incidence and risk factors remain unknown. Results: The reports of 29 trials were analyzed. WebCisplatin is similar to the bifunctional alkylating agents. It covalently binds to DNA and disrupts DNA function. 6. ... Hypophosphatemia and hyponatremia have occurred in some patients receiving cisplatin combination regimens. 2. These effects are due to renal tubular damage. Cisplatin greatly increases the urinary excretion of magnesium and bit by bit facebook

Cisplatin-induced hyponatremia in malignancy: comparison …

WebMar 15, 2024 · For patients who are unable to receive cisplatin due to medical frailty or comorbidities, options include a carboplatin-based regimen ( carboplatin plus gemcitabine, or carboplatin, gemcitabine, and paclitaxel) or a non-platinum-based combination (eg, paclitaxel plus gemcitabine) or even monotherapy (eg, gemcitabine). WebSep 1, 2024 · Cisplatin for injection has been administered at 20 mg/m 2 intravenously daily for 5 days per cycle. Other doses and combination regimens have been used. ... other electrolyte abnormalities (hypocalcemia, hyponatremia, hypokalemia, and hypophosphatemia), Syndrome of Inappropriate Antidiuretic Hormone Excretion … bit_by_bit_fastWebJan 1, 2024 · Hyponatremia in cancer patients can be caused by a number of factors including gastrointestinal losses, cardiac failure, diabetes insipidus, cancer-induced … darwin homes llc

"WebRisk Factors for Severe Hyponatremia Related to Cisplatin: A Retrospective Case-Control Study. Onset of severe hyponatremia following cisplatin (CDDP) administration … " - Cisplatin hyponatremia

Cisplatin hyponatremia

Risk factors for severe hyponatremia related to cisplatin: a ...

WebMar 1, 2024 · Cisplatin is a well‐known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude of renal disorders including acute kidney injury with reduced glomerular filtration, Fanconi syndrome, and renal tubular acidosis, nephrogenic diabetes insipidus and renal salt wasting syndrome. WebHyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) or gastrointestinal loss of sodium is sometimes seen during chemotherapy. However, …

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WebApr 27, 2024 · Hyponatremia is a common adverse effect induced by cisplatin. Caution should be exercised with patients with a low sodium level before starting chemotherapy. Hyponatremia can be associated with other chemotherapy-related adverse effects, and it should therefore be treated correctly. Introduction WebJun 2, 2024 · e24105 Background: Cisplatin-associated acute kidney injury (C-AKI) is common. Predictive factors of C-AKI include age > 60 years, hypertension, cisplatin dose, diabetes, and serum albumin < 3.5g/L. The association between C-AKI and hypokalemia, hypomagnesemia or hyponatremia has not been well characterized to date. Methods: …

WebJul 1, 2008 · Hyponatremia associated with platinum compounds is described more frequently with cisplatin than with carboplatin. 42, 43 The possible underlying pathophysiological mechanisms by which cisplatin induces hyponatremia are SIADH and renal salt wasting. 44 Cisplatin-induced hyponatremia often is combined with … WebFeb 16, 2024 · Cisplatin Dosage Medically reviewed by Drugs.com. Last updated on Feb 16, 2024. Applies to the following strengths: 50 mg; 10 mg; 1 mg/mL Usual Adult Dose for: Testicular Cancer Ovarian Cancer Bladder Cancer Usual Pediatric Dose for: Testicular Cancer Ovarian Cancer Bladder Cancer Additional dosage information: Renal Dose …

http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf WebHyponatremia of grade 3 or above developed in 30.7% of the generic CDDP group compared to 15.1% of the brand-name CDDP group ( P =0.011). Multivariate analysis showed that the use of generic CDDP increased the incidence of hyponatremia (odds ratio =5.661, 95% confidence interval =1.403–22.839; P =0.015). Conclusion: Oncologists …

WebMay 19, 2024 · Cisplatin treatment may cause hyponatremia through SIADH, related to both higher secretion of and sensitivity to ADH ( 32 ). Nausea and vomiting, which are common side effects of platinum …

WebNational Center for Biotechnology Information darwin homes fundingWebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose … darwin homes logoWebWe report a case of a patient with hyponatremia and excessive urinary excretion of sodium after cisplatin-based chemotherapy. RSWS was diagnosed and the patient was treated … darwin homes property management phone numberWebApr 7, 2024 · Acute overdosage of spironolactone tablets may be manifested by drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Rarely, instances of hyponatremia, hyperkalemia, or hepatic coma may occur in patients with severe liver disease, but these are unlikely due to acute overdosage. darwin homes ohioWebOnset of severe hyponatremia following cisplatin (CDDP) administration has been previously reported. However, the risk factors associated with hyponatremia still remain unclear. We conducted a retrospective, single-center, case-control study to identify independent risk factors of severe hyponatremia in patients with various types of cancers. darwin homes cleveland ohioWebAug 18, 2024 · Water losses from brain cells cause neurologic symptoms. Volume expansion and dilutional hyponatremia, without neurologic symptoms, can also be induced when isotonic mannitol is used as a flushing solution during transurethral resection of the prostate or bladder. bit by bit fletch songWebNational Center for Biotechnology Information bit by bit gisborne