WebJan 25, 2024 · The key components that execute SV acidification and neurotransmitter filling are the proton-pumping vacuolar H + -ATPases (vATPases) and the vesicular neurotransmitter transporters. 7, 8 These two groups of proteins initiate distinct processes: the vATPases form a proton electrochemical gradient (Δμ H+) across the membrane by … WebSep 1, 2006 · A new study shows that alveolar macrophages use the cystic fibrosis transmembrane-conductance regulator (CFTR) to maintain lysosomes at low pH and to …
Trafficking and function of the cystic fibrosis transmembrane ...
Webof endogenous V-ATPase (24) and CFTR (46). Moreover, cAMP-stimulated traffic of V-ATPase and CFTR from subap-ical endosomes into the apical membrane of Brunner’s gland acinar cells was dependent on PKA (24). The functional implication of V-ATPase association with CFTR was not examined in those studies due to inaccessibility of the gland WebNov 1, 2013 · In the intestine, cAMP-dependent traffic of cystic fibrosis transmembrane conductance regulator (CFTR) channels and the sodium hydrogen exchanger (NHE3) in the brush border regulate luminal pH. V-ATPase was found to colocalize with CFTR in intestinal CFTR high expresser (CHE) cells recently. internship sidoarjo
CFTR - What does CFTR stand for? The Free Dictionary
WebThe regulation of lysosomal acidification involves the proper coordinated function of multiple ion channels and most notably, the vacuolar ATPase, the macromolecular complex responsible for pumping protons (H+) into lysosomes and lowering intraluminal pH to the acidic range needed to activate the dozens of hydrolases with acidic pH optima in … WebAug 8, 2011 · V-ATPase regulation by mTORC1 involves a transcription factor translocated in renal cancer, TFEB. TFEB is required for the expression of a large subset of mTORC1 responsive genes. mTORC1 coordinately regulates TFEB phosphorylation and nuclear localization and in a manner dependent on both TFEB and V-ATPases, mTORC1 … WebAug 8, 2011 · V-ATPase regulation by mTORC1 involves a transcription factor translocated in renal cancer, TFEB. TFEB is required for the expression of a large subset of mTORC1 … internships huntsville alabama