Bitler and claudin-4

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WebJul 21, 2024 · Claudin-4, a protein with the structure of classic claudins most often found in cell-cell junctions, is frequently overexpressed in epithelial cancers; it is le. ... (Bitler, … WebOct 1, 2024 · Claudin-4 phosphorylated on tyrosine 208 does not overlap with non-phosphorylated claudin-4. ... Benjamin G. Bitler was supported by Department of Defense, USA [OC170228, OC200302, OC200225], American Cancer Society [RSG-19-129-01-DDC], Division of Cancer Prevention, National Cancer Institute [R37CA261987].

Loss of claudin-4 reduces DNA damage repair and ... - ScienceDirect

WebClaudin-4 immunohistochemistry was performed on cell-block paraffin sections and scored for staining intensity, staining pattern (cytoplasmic versus membranous), and percentage of positive tumor cells. Appropriate positive and negative controls were used throughout. Results: All cases of mesothelioma were negative for claudin-4 (0 of 64 ... WebROBERT T. BUTLER ET AL. v. CATHY SUE FRIEDEN, AN INFANT, ETC. Record No. 6485. Supreme Court of Virginia. December 4, 1967. Present, Eggleston, C.J., and … photo manif retraite

Claudin-4 as a marker for distinguishing malignant ... - PubMed

WebJan 13, 2014 · Claudin-4 is a tight-junction-associated protein that is expressed in most epithelial cells but is absent in mesothelial cells. 12 Immunohistochemistry for claudin-4 has recently been shown to distinguish adenocarcinoma from malignant mesothelioma with high sensitivity and specificity, mostly in surgical specimens. 13-18 Our aim was to validate ... WebMar 11, 2002 · Distinct from claudin-1, claudin-4 was distributed mainly in the second/third layers of stratum granulosum (a). Claudin-4 was also concentrated at the occludin-positive lines circumscribing granular cells (arrowhead) (b). SC, stratum corneum. The broken line represents the dermis/epidermis border. Bars, 20 μm. WebApr 1, 2013 · D. Claudin-4. Claudin-4 is most strongly expressed in the kidney, primarily in the collecting ducts, and in the lung. In vitro, depending on the cell type investigated, it acts either as a general barrier , as a Na + barrier without affecting Cl − permeability (364, 365) or, when interacting with claudin-8, as a Cl − /anion pore . how does hydration affect bread

Claudin-4 localization in epithelial ovarian cancer: Heliyon

Age-Related Changes of Claudin Expression in Mouse Liver, …

WebMay 15, 2004 · By contrast, when claudin-3 is introduced into MDCK I cells, no change in their TER is detected. Claudin-2 thus markedly decreases the `tightness' of individual claudin-1/claudin-4-based TJ strands, providing support for the hypothesis that different combinations of claudins determine the barrier properties of individual TJ strands. WebJul 23, 2024 · The claudin-family proteins are a group of tight-junction membranous proteins responsible for paracellular molecular flow between adjacent cells of the epithelium. 1 In normal kidney, claudin-4 plays a key role in paracellular ion reabsorption. 2 Claudin-4 is expressed in most epithelial cells yet is absent in mesothelial cells, making it of great … photo manifestation iranWebClaudin-4 was thus considered very useful marker for distinguishing mesothelioma and adenocarcinoma, even if histological specimens are small, as in biopsies that contain limited numbers of tumor cells. However, it should be mentioned that claudin-4 has a limit in discrimination between squamous cell carcinoma from mesothelioma. photo manipulation alex hermione

"WebSep 24, 2024 · The increase of claudin-4 in rat colon after chronic DMH exposure was consistent with the acute effect of DMH on IPEC-J2 cells, which may indicate an essential role of this protein in colorectal cancer development. ... P.G.; Galimanis, C.E.; Bitler, B.G.; Behbakht, K.; Baumgartner, H.K. Ovarian Tumor Cell Expression of Claudin-4 Reduces ... " - Bitler and claudin-4

Bitler and claudin-4

Claudin 4 Monoclonal Antibody (3E2C1) (32-9400)

WebApr 1, 2024 · Knockdown of claudin-4 has recently been found to sensitize ovarian cancer cells to paclitaxel and PARP inhibitors (Breed et al., 2024, Yamamoto et al., 2024 and targeting of claudin-3 and claudin ...

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WebAug 19, 2009 · In addition to claudin-4, the levels of most claudin decreased significantly with age, except for claudin-2 and -7 where the decrease was observed only in females . Again, when the male and female mice were examined as group at multiple points, most claudins exhibited a trend toward being expressed at lower levels in aged animals ( … WebAug 1, 2024 · Objectives: Claudin-4 is aberrantly expressed in nearly 70% of all ovarian cancer tumors, and increased claudin-4 expression conveys a worse overall survival. Poly (ADP-ribose) polymerase (PARP) inhibitors are a therapeutic option for patients with ovarian cancer. PARP inhibitors exploit deficiencies in DNA damage repair (e.g., BRCA …

WebAug 15, 2005 · Abstract. Claudin proteins form a large family of integral membrane proteins crucial for tight junction formation and function. Our previous studies have revealed that claudin-3 and claudin-4 proteins are highly overexpressed in ovarian cancer. To clarify the roles of claudins in ovarian tumorigenesis, we have generated human ovarian surface … WebNov 1, 2005 · Abstract. The tight junction proteins claudins are abnormally regulated in several human cancers. In particular, claudin-3 and claudin-4 are frequently …

WebAug 4, 2024 · Epithelia act as a barrier between the internal and external environments, and the movement of substances via the paracellular pathway is regulated by tight junctions (TJs). Claudins are major determinants of TJ permeability. Claudin-4 was the first claudin whose involvement in the TJ permeability in cultured cells was directly demonstrated, but … WebBradley W. Butler (704) 666-8602 Email me Immigration Criminal Defense Creighton University School of Law, Omaha, Nebraska J.D., Doctor of Jurisprudence - 1990 …

WebThe tight junction protein claudin-4 has been reported to be overexpressed in advanced ovarian cancer. We investigated the prognostic significance of claudin-4 overexpression and whether claudin-4 ...

WebMichael Koval, in Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease, 2024. 1.4.2.2 Claudin-4. Claudin-4 also is prominently expressed throughout the lung … how does hydration affect biaWebNov 17, 2024 · FIGURE 1.Claudin-1, claudin-2, claudin-3, claudin-4, and claudin-8 expression in control human colon and colon of IBD patients. (A) Overview of claudin-1, claudin-2, claudin-3, claudin-4, and claudin-8 expression pattern (IHC); (B) claudin mRNA expressed as ΔCT value from claudin CT normalized to the GAPDH CT. Data … photo manifestationWebJan 13, 2014 · Claudin-4 is a tight-junction-associated protein that is expressed in most epithelial cells but is absent in mesothelial cells. 12 Immunohistochemistry for claudin-4 … how does hydration affect blood flowWebCancer Cytopathol. 2014 Apr;122(4):299-306. 2. Ohta Y, Sasaki Y, Saito M, et al: Claudin-4 as a marker for distinguishing malignant mesothelioma from lung carcinoma and serous adenocarcinoma. Int J Surg Pathol. 2013 Oct;21(5):493-501. 3. Ordonez NG: Value of claudin-4 immunostaining in the diagnosis of mesothelioma. Am J Clin Pathol. 2013 May ... photo manifestation retraiteWebClaudin-4 is found associated with CLAUDIN-8 in the KIDNEY COLLECTING DUCT where it may play a role in paracellular chloride ion reabsorption. publications Timeline Most … how does hydration affect performanceWebCLDN3. Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene. [5] It is a member of the claudin protein family. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and ... how does hydration affect vital signsWebMar 18, 2024 · The role of claudins in maintaining cell barrier as well as small ions and neutral solutes selective transport is crucial: experimental claudins knockout models lacking CLDN1 and CLDN5 are lethal [14,15].Overexpression of claudin-1, claudin-4, claudin-5, and claudin-7 increase transepithelial resistance (TER), whereas claudin-2 and claudin … how does hydraulic crane works